L – Glutathione – Effervescent Tablets

Glutathione helps tissue building and repair by synthesizing chemicals and proteins required for the body.

In conditions such as

• Alcoholism
• Asthma, cancer, heart disease
• Hepatitis, liver disease
• Memory loss, Alzheimer’s disease, osteoarthritis G Parkinson’s disease.
• Diseases that weaken the body’s defense system (including AIDS & chronic fatigue syndrome)
• Cataracts & glaucoma Atherosclerosis and high cholesterol

Glutathione Plays a very important role in helping to provide support

Has a synergistic effect in combination with Vitamin C

Role of Vitamin C

• Helps increase glutathione levels by attacking free radicals first, thereby sparing glutathione. Helps reprocess glutathione by converting oxidized glutathione back to its active form
• Powerful antioxidant

Glutathione as a skin whitening agent

Glutathione is a low molecular weight thiol-tripeptide that plays a prominent role in maintaining intracellular redox balance. In addition to its remarkable antioxidant properties, the discovery of its antimelanogenic properties has led to its promotion as a skin-lightening agent. It is widely used for this indication in some ethnic populations. However, there is a dichotomy between evidence to support its efficacy and safety. The hype around its depigmentary properties may be a marketing gimmick of pharma-cosmeceutical companies. This review focuses on the various aspects of glutathione: its metabolism, mechanism of action and the scientific evidence to evaluate its efficacy as a systemic skin-lightening agent. Glutathione is present intracellularly in its reduced form and plays an important role in various physiological functions. Its skin-lightening effects result from direct as well as indirect inhibition of the tyrosinase enzyme and switching from eumelanin to phaeomelanin production. It is available in oral, parenteral and topical forms. Although the use of intravenous glutathione injections is popular, there is no evidence to prove its efficacy. In fact, the adverse effects caused by intravenous glutathione have led the Food and Drug Administration of Philippines to issue a public warning condemning its use for off-label indications such as skin lightening. Currently, there are three randomized controlled trials that support the skin-lightening effect and good safety profile of topical and oral glutathione. However, key questions such as the duration of treatment, longevity of skin-lightening effect and maintenance protocols remain unanswered. More randomized, double-blind, placebo-controlled trials with larger sample size, long-term follow-up and well-defined efficacy outcomes are warranted to establish the relevance of this molecule in disorders of hyperpigmentation and skin lightening.